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目的 探讨新生儿期后脑活素多疗程治疗对新生儿缺氧缺血性脑病 (HIE)预后的影响。方法 丽珠赛乐 5ml/d ,静脉滴注连续 10～ 14天为一疗程 ,间隔 2 0～ 30天用下一疗程 ,共 4～ 6个疗程 ,3、6、12、18、2 4、30个月时用儿心量表检测精神运动发育商 (DQ)。结果 随访至 30个月时 ,治疗组 92例中 76例DQ在 90以上 ,占 82 6 % ,6例有后遗症DQ <75 ,伤残率 6 5 2 % ;对照组 2 4例中 ,13例DQ在 90以上 ,8例有后遗症 ,伤残率为 33 3 % ,两组差异显著。相同月龄两组间各能区得分比较 ,治疗组高于对照组 ,差异显著。结论 新生儿期后丽珠赛乐多疗程治疗可减少神经系统后遗症的发生、明显改善HIE预后
Objective To investigate the effect of multi-treatment of cerebrolysin during neonatal period on the prognosis of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Cristallola 5ml / d, intravenous infusion of 10 to 14 days for a course of treatment interval 20-30 days with the next course of treatment, a total of 4 to 6 courses, 3,6,12,18,24, At 30 months, the psychomotor development (DQ) was measured with a heart rate monitor. Results At the follow-up of 30 months, 76 of the 92 patients in the treatment group had a DQ of 90 or more, accounting for 82.6%. Six patients had sequelae of DQ <75 and a disability rate of 52.2%. Among the 24 patients in the control group, 13 DQ in 90 or more, 8 cases have sequelae, disability rate was 33 3%, significant difference between the two groups. The same month age scores between the two groups can be compared, the treatment group was higher than the control group, the difference was significant. Conclusions After neonatal period, treatment with radium saxophylla can reduce the incidence of nervous system sequelae and improve the prognosis of HIE