论文部分内容阅读
目的:制备吴茱萸次碱(Rut)固体分散体,提高.Rut体外溶出度。方法:分别以聚乙烯吡咯烷酮(PVP)为载体,采用溶剂-共沉淀法,制备含不同辅助载体的Rut固体分散体;采用差示热分析和X-射线衍射分析对固体分散体进行物相鉴别,并进行体外溶出度试验;考察载体用量、载体中表面活性剂的加入和不同溶出介质对药物溶出特性的影响。结果:Rut以微晶形式存在于固体分散体中;其中,以微粉硅胶和乳糖为辅助载体制备的Rut-PVP-微粉硅胶(1:2:1)和Rut-PVP-乳糖(1:2:2)固体分散体,其累积溶出度较其物理混合物提高了约6倍。结论:Rut-PVP-微粉硅胶(1:2:1)和Rut-PVP-乳糖(1:2:2)固体分散体可显著提高药物的溶出速度和程度。
Objective: To prepare Rut solid dispersions and improve the in vitro dissolution rate of Rut. Methods: Solvent-coprecipitation method was used to prepare Rut solid dispersions with different auxiliary carriers using polyvinylpyrrolidone (PVP) as carrier. Solid phase dispersions were identified by differential thermal analysis and X-ray diffraction , And in vitro dissolution test; study the amount of carrier, the carrier of surfactant and different dissolution medium on the dissolution characteristics of the drug. Rut-PVP-silica gel (1: 2: 1) and Rut-PVP-lactose (1: 2: 1) were prepared in the form of microcrystals. 2) The solid dispersion, the cumulative dissolution of its physical mixture increased by about 6 times. Conclusion: The solid dispersion of Rut-PVP-Silica gel (1: 2: 1) and Rut-PVP-Lactose (1: 2: 2) can significantly improve the dissolution rate and extent of the drug.