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目的 观察羟基喜树碱 (HCPT)联合方案经肝动脉灌注栓塞治疗手术无法切除的原发性肝癌的效果。方法 按Seldinger法经皮股动脉穿刺插管或手术置入肝动脉植入式药泵后 ,给予HCPT +5 Fu+MMC +碘化油行化疗栓塞治疗 38例原发性肝癌。结果 有效率 (CR +PR) 4 2 .1% (16 38) ,半年生存率为 84 2 % ,1年生存率为 5 2 6 % ,毒副作用以消化道反应和骨髓抑制、发热为主。结论 含HCPT方案经肝动脉灌注栓塞化疗对中晚期原发性肝癌疗效确切 ,副反应轻
Objective To observe the effect of hydroxycamptothecin (HCPT) combined with hepatic arterial infusion and embolization in the treatment of unresectable primary liver cancer. Methods Seldinger method percutaneous femoral artery puncture intubation or surgery into the hepatic artery implantation pump, given HCPT +5 Fu + MMC + iodized oil chemoembolization in 38 cases of primary liver cancer. Results The effective rate (CR + PR) was 42.1% (16 38). The half-year survival rate was 84.2% and the one-year survival rate was 52.6%. The side effects were gastrointestinal reaction, bone marrow suppression and fever. Conclusion HCPT regimen with hepatic artery perfusion and chemoembolization has definite curative effect on advanced primary liver cancer with mild side effects