论文部分内容阅读
目的观察不同剂量阿托伐他汀对冠脉介入术后患者血脂、脂联素和炎性因子的影响。方法选择2015年7月-2016年9月接受经皮冠状动脉介入术(PCI)治疗的急性冠脉综合征患者135例,采用数字表法随机分为3组,每组45例。所有患者均接受PCI术治疗,并在术后均采用抗凝剂、硝酸酯类及受体阻滞剂等药物进行常规治疗。术后第2天,3组患者均给予阿托伐他汀睡前口服治疗,A组20 mg,B组40 mg,C组80 mg,均每天1次。比较3组治疗前后血脂、脂联素、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-α)及白细胞介素-6(IL-6)水平。结果 3组治疗前总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)比较差异均无统计学意义(P>0.05)。治疗后3组TC均降低,与治疗前比较差异均有统计学意义(P<0.05);治疗后3组TG均降低,但A组、B组治疗前后比较差异均无统计学意义(P>0.05),C组治疗前后比较差异均有统计学意义(P<0.05);治疗后3组LDL-C均降低,HDL-C均升高,但A组治疗前后比较差异无统计学意义(P>0.05),B组、C组治疗前后比较差异均有统计学意义(P<0.05)。治疗后TC、TG、HDL-C和LDL-C C组优于A组和B组,B组优于A组,差异均有统计学意义(P<0.05)。3组治疗前脂联素、CRP、TNF-α和IL-6比较差异无统计学意义(P>0.05),治疗后脂联素、CRP、TNF-α及IL-6水平均有所改善(P<0.05),且C组优于A组和B组,B组优于A组,差异均有统计学意义(P<0.05)。结论对冠脉介入术后患者采用大剂量阿托伐他汀,能够降低血脂,提高脂联素水平以及促进炎性反应降低,值得应用。
Objective To observe the effects of different doses of atorvastatin on serum lipids, adiponectin and inflammatory factors in patients after coronary intervention. Methods Thirty-five patients with acute coronary syndrome who underwent percutaneous coronary intervention (PCI) from July 2015 to September 2016 were randomly divided into three groups (45 in each group) by digital meter. All patients underwent PCI and were treated routinely with anticoagulants, nitrates, and blockers. On the second day after operation, atorvastatin was given orally at bedtime in 3 groups, 20 mg in group A, 40 mg in group B, and 80 mg in group C, all at once daily. The levels of serum lipids, adiponectin, CRP, TNF-α and IL-6 in the three groups before and after treatment were compared. Results There were no significant differences in the levels of TC, TG, LDL-C and HDL-C between the three groups before treatment (P> 0.05 ). After treatment, TC in three groups decreased, with statistical significance (P <0.05) before treatment; TG in three groups decreased after treatment, but there was no significant difference between A group and B group before and after treatment (P> 0.05). There was significant difference between before and after treatment in group C (P <0.05). LDL-C in three groups decreased and HDL-C increased after treatment, but there was no significant difference between before and after treatment in group A (P > 0.05). There was significant difference between before and after treatment in group B and group C (P <0.05). The levels of TC, TG, HDL-C and LDL-C in treatment group were better than those in group A and B, and the difference was statistically significant (P <0.05). The levels of adiponectin, CRP, TNF-α and IL-6 before treatment in three groups had no significant difference (P> 0.05). The levels of adiponectin, CRP, TNF-α and IL- P <0.05), and C group was better than A group and B group, B group was better than A group, the difference was statistically significant (P <0.05). Conclusions The use of high-dose atorvastatin in patients after coronary intervention can lower blood lipids, increase the level of adiponectin and decrease the inflammatory response, which is worthy of application.