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目的探讨高浓度孕激素对卵巢癌细胞株HO-8910体外生长的作用。方法用细胞凋亡检测试剂盒判定细胞凋亡,用光镜、电镜观察细胞变化。结果孕激素浓度为200、500ng/mL时,对细胞的生长影响与对照组比较无显著差异;孕激素浓度为1000、2000、3000、4000、5000ng/mL时,与对照组比较有显著差异。结论高浓度孕素对卵巢癌细胞株HO-8910的生长有抑制作用,呈剂量依赖效应。
Objective To investigate the effect of high concentration progestin on the growth of ovarian cancer cell line HO-8910 in vitro. Methods Apoptosis was determined by apoptosis detection kit. The changes of cells were observed by light microscope and electron microscope. Results When the concentration of progesterone was 200,500ng / mL, there was no significant difference between the two groups in the growth of cells. When the concentration of progesterone was 1000,2000,3000,4000,5000ng / mL, there was a significant difference compared with the control group. Conclusion High concentration progesterone can inhibit the growth of ovarian cancer cell line HO-8910 in a dose-dependent manner.