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目的 研究大肠癌中P21~(ras)、P53表达及临床病理意义。方法 用链霉菌抗生物素蛋白—过氧化酶免疫组化染色技术(SP法)检测80例大肠癌组织P21~(ras)、P53表达。结果 大肠癌原发病灶中P21~(ras)、P53的阳性表达率分别为71.3％及53.8％。癌组织二种蛋白同时表达占42.5％。P21~(ras)的阳性表达与肿瘤的组织类型、肿瘤浸润深度、淋巴结转移有关;P53的阳性表达与临床病理指标均无统计学意义。结论 P21~(ras)及P53可能与大肠癌的发生有关,二者在大肠癌的发生中可能起协同作用,其蛋白阳性表达与预后无相关性。
Objective To study the expression of P21 ras and P53 in colorectal carcinoma and its clinicopathological significance. Methods The expression of P21 ras and P53 in 80 cases of colorectal carcinoma was detected by Streptavidin - peroxidase immunohistochemical staining (SP method). Results The positive rates of P21 ras and P53 in primary colorectal cancer were 71.3% and 53.8% respectively. Cancer tissue two proteins simultaneously accounted for 42.5%. The positive expression of P21 ras was related to the type of tumor, depth of tumor invasion and lymph node metastasis. The positive expression of P21 ras was not related to the clinicopathological parameters. Conclusions P21 ras and P53 may be involved in the carcinogenesis of colorectal cancer. Both of them may play a synergistic role in the carcinogenesis of colorectal cancer. The expression of P21 ras and P53 may not correlate with prognosis.