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恶性疟原虫环子孢子蛋白(CS)中央区的一组重复四肽链可望成为抗子孢子疫苗的有效组成,但鼠实验发现对分离、重组及合成CS多肽的应答均受T-细胞应答的限制。流行病学调查提示人对CS蛋白应答亦受组织相容性复合体(MHC)的制约。泰国恶性疟成人患者中17％对CS无抗体反应,30％对重组CS多肽(R32tet32)不能激发无淋巴细胞免疫反应。鉴于对蛋白质抗原的免疫应答受MHCⅡ类分子控制,作者在泰国恶性疟患者中研究了HLA-DR/DQ表型与抗子孢子特异性免疫应答的关系。受试者均为20～30岁男性确诊患者。每例取急性期和恢复期血样进行抗体反应,淋
A set of repeated tetrapeptide chains in the central region of Plasmodium falciparum circumsporozoite protein (CS) is expected to be an effective component of the anti-sporozoite vaccine, but in murine experiments the responses to isolated, recombinant and synthetic CS polypeptides are both T-cell responsive limits. Epidemiological investigations suggest that human response to CS protein is also restricted by the histocompatibility complex (MHC). 17% of thallus falciparum adult patients had no antibody response to CS and 30% of recombinant CS polypeptides (R32tet32) failed to elicit a lymphocyte-free immune response. In view of the fact that the immune response to protein antigens is controlled by MHC class II molecules, the authors studied the relationship between the HLA-DR / DQ phenotype and anti-sporozoite-specific immune responses in patients with falciparum malaria in Thailand. Subjects were 20 to 30-year-old male diagnosed patients. Each case of acute and convalescent blood samples for antibody response, leaching