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[目的]观察单肺通气（one-lung ventilation ，OLV ）期间雾化吸入长托宁对肺内分流率（Qs/Qt）、氧合指数（oxygenation index ，OI）和血乳酸（blood lactic acid ，BLA）水平的影响。[方法]选择28例OLV行开胸手术的患者，随机分长托宁组（P组，于O L V期间雾化吸入长托宁）和对照组（C组）。分别于O L V前15 min（T0）、OLV 15 min（T1）、OLV 45 min（T2）抽动脉血与混合静脉血行血气分析及BLA测定，计算Qs/Qt与OI 。[结果]OLV后两组OI均下降，但P组较C组下降缓慢，且P组T2较T1有所回升；OLV后两组Qs/Qt和BLA均增加，但P组比C组增加较慢，且P组T2较T1有所下降。[结论]OLV期间雾化吸入长托宁能改善氧合，降低肺内分流。“,”[Objective]To observe the impact of aerosolized penehyclidine hydrochloride inhalation on in-trapulmonary shunt fraction(Qs/Qt) ,oxygenation index(OI) and blood lactic acid(BLA) during one-lung ven-tilation(OLV) .[Methods]Twenty eight patients with OLV undergoing open chest operation were chosen and randomly divided into penehyclidine hydrochloride group(group P ,aerosolized penehyclidine hydrochloride in-halation during OLV) and control group(group C) .Arterial and mixed venous blood were drawn for blood gas analysis and BLA detection 15min before OLV (T0 ) ,15min(T1 ) and 45min after OLV (T2 ) .Qs/Qt and OI were calculated .[Results]After OLV ,OI in two groups decreased ,but that in group P decreased more slowly than that in group C .Compared with T1 ,OI in group P at T2 rose again .After OLV ,Qs/Qt and BLA in two groups increased ,but that in group P increased more slowly than that in group C .Compared with T1 ,Qs/Qt and OI in group P at T2 declined again .[Conclusion]Aerosolized penehyclidine hydrochloride inhalation during OLV can improve oxygenation and decrease intrapulmonary shunt .