The Stokes polarimeter based on liquid crystal variable retarders(LCVRs)is envisaged as a promising novel technique for polarization measurement in space applications due to the inherent advantage of eliminating the need for conventional rotating polarizing optics and increasing the measuring speed.However,the intrinsic multi-beam interference in LCVRs limits its polarization accuracy by several percent.How to eliminate the influence of the interference effect becomes an urgent issue for the liquid-crystal-based Stokes polarimeter.The present study introduces a simplified but effective inter-ference model based on the thin-film optics and polarized light theory to simulate the relationship between the interference effect of the LCVRs-based Stokes polarimeter and the polarization accuracy.The simulation results show that the transmit-tance variation of LCVR with the derived voltage is caused by multi beam interference between the indium tin oxide(ITO)film and the liquid crystal within LCVR,which produces a few percent of instrumental polarization.The instrumental polarization is about 0.01 and different for different wavelengths.An optimization method was proposed to reduce the in-strumental polarization to 0.002,effectively improving the polarization sensitivity of the Stokes polarimeter limited by the interference.In addition,an experimental setup was built up to measure and analyze the influence of the interference effect of the LCVRs-based Stokes polarimeter on the polarization accuracy before and after the optimization.The experiment results are in good agreement with the simulation.