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目的 研究椎动脉阻断对小脑组织及颈脊髓功能的影响。方法 将杂种家犬按处死时间分为 1d组 ,7d组 ,2 8d组及对照组 ,每组 5条犬。结扎犬颈 4 ,颈 5水平双侧椎动脉 ,于术后 1、7、2 8d分别观察犬行为 ,诱发电位 ,颈脊髓与小脑后下叶的影像 ,组织学的变化及毛细血管灌注的定量分析。结果 术后 1d组动物出现轻度缺血性损害 ,其余动物椎动脉阻断后小脑后下叶及颈脊髓组织无明显改变。结论 颈内动脉可以短期内完成对椎动脉阻断后的缺血代偿。椎动脉血流障碍并非椎动脉型颈椎病的主要病理机制 ,而该动物模型可以节段性模拟人类颈脊髓的微循环。
Objective To study the effect of vertebral artery occlusion on the function of cerebellum and cervical spinal cord. Methods The hybrid dogs were divided into 1d group, 7d group, 28d group and control group with 5 dogs in each group. The bilateral cervical vertebral arteries at the level of 4 and 5 were ligated. The dogs’ behavior and evoked potentials were observed at 1, 28 and 28 days after operation. The images of cervical spinal cord and posterior inferior cerebellar, histological changes and the quantitative perfusion of capillaries analysis. Results In the first day after operation, mild ischemic injury occurred in the animals and no change was observed in the posterior inferior cerebrum and cervical spinal cord after the occlusion of other animals. Conclusion The internal carotid artery can shorten the ischemic compensation after the block of the vertebral artery. Vertebral artery blood flow disorder is not the main pathological mechanism of cervical spondylosis of vertebral artery, and the animal model can segment the microcirculation of human cervical spinal cord.