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目的探讨乙型肝炎后肝硬化反复发作的影响因素。方法随机抽取2015年3月-2016年3月该院收治的反复发作的乙型肝炎肝硬化患者65例为试验组,以同期收治的首次发病的乙型肝炎肝硬化患者65例为对照组。比较2组临床资料,分析影响肝硬化反复发作的因素。结果试验组患者病程≥5年、手术创伤、肝损伤药物应用、乙肝病毒DNA定量高、过度劳累、甜食摄入过量、饮酒史所占比例均显著高于对照组,差异均有统计学意义(P<0.05)。结论影响乙型肝炎肝硬化反复发作的因素包括病程、手术创伤、肝损伤药物应用、乙肝病毒DNA定量高、过度劳累、甜食摄入过量、饮酒史等,临床治疗过程中应引起高度重视,采取积极措施减少或消除这些因素的影响,控制乙型肝炎肝硬化发作次数,改善患者预后。
Objective To investigate the influencing factors of recurrent cirrhotic hepatitis after hepatitis B Methods Totally 65 patients with recurrent hepatitis B cirrhosis admitted in our hospital from March 2015 to March 2016 were selected as the experimental group and 65 patients with the first incidence of hepatitis B cirrhosis who were treated in the same period as the control group. The clinical data of two groups were compared to analyze the factors influencing recurrent cirrhosis. Results The duration of disease in trial group was more than 5 years. The surgical trauma, drug application of liver injury, high quantitative hepatitis B virus DNA, over-exertion, over-consumption of sweets and the history of drinking history were significantly higher than those of the control group P <0.05). Conclusions The factors influencing the recurrent hepatitis B cirrhosis include course of disease, surgical trauma, drug application of liver injury, high quantitative DNA of hepatitis B virus, over exertion, overdrinking of sweets and history of alcohol consumption, which should be paid more attention in the course of clinical treatment. Positive measures to reduce or eliminate the impact of these factors, control the number of hepatitis B cirrhosis, improve patient prognosis.