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在先天性心脏病中，肺循环合成及分泌内皮素（ＥＴ）增加，且与肺动脉压力及肺循环量呈正相关。在心力衰竭、肺源性心脏病、原发性肺动脉高压、新生儿肺动脉高压及高原性肺动脉高压中，均有肺循环内ＥＴ合成及分泌增加，且与肺动脉压力呈正相关，提示肺血流动力学变化是各种肺动脉高压时肺ＥＴ分泌增加的共同机理，抑或两者互为因果。ＥＴ参与了各种原因所致肺动脉高压的形成
In congenital heart disease, pulmonary circulation synthesis and secretion of endothelin (ET) increased, and pulmonary artery pressure and pulmonary circulation was positively correlated. In heart failure, cor pulmonale, primary pulmonary hypertension, neonatal pulmonary hypertension and high altitude pulmonary hypertension, both ET synthesis and secretion in the pulmonary circulation increased, and positively correlated with pulmonary artery pressure, suggesting that pulmonary hemodynamics Change is a common mechanism of increased pulmonary ET secretion in a variety of pulmonary hypertension, or the two are mutually causal. ET is involved in the formation of pulmonary hypertension due to various causes