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目的探讨内毒素(LPS)对幼龄大鼠肺、小肠和脾内诱导性一氧化氮合酶(iNOS)的影响。方法用免疫组织化学方法显示iNOS免疫活性表达。结果LPS可增力。肺、小肠和脾内巨噬细胞、中性粒细胞和嗜酸性粒细胞iNOS的表达。结论iNOS在不同细胞和器官的表达与注射LPS后的病理变化密切相关。
Objective To investigate the effects of endotoxin (LPS) on inducible nitric oxide synthase (iNOS) in the lung, small intestine and spleen of young rats. Methods The expression of iNOS immunoreactivity was detected by immunohistochemistry. LPS can increase the power. Expression of iNOS in lung, small intestine and spleen in macrophages, neutrophils and eosinophils. Conclusion The expression of iNOS in different cells and organs is closely related to the pathological changes after LPS injection.