ｐ16基因又称多肿瘤抑制基因,是新近发现的肿瘤抑制基因,其在许多肿瘤细胞系和肿瘤组织中存在缺失和点突变。ｐ16基因失活与多种肿瘤的发生相关,但目前有关ｐ16基因在原发性胆囊癌中表达的研究甚少。本研究采用免疫组化方法检测了ｐ16基因在原发性胆囊癌及慢性胆囊炎组织中的表 The p16 gene, also known as a multiple tumor suppressor gene, is a recently discovered tumor suppressor gene that has deletions and point mutations in many tumor cell lines and tumor tissues. The inactivation of p16 gene is associated with the occurrence of multiple tumors. However, little is known about the expression of p16 gene in primary gallbladder cancer. In this study, the expression of p16 gene in primary gallbladder carcinoma and chronic cholecystitis was detected by immunohistochemistry.