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目的研究原发性痛风与伴发病 (冠心病、高血压病、高脂血症、糖尿病 )的关系。方法总结 1989年1月～ 1998年 3月间收治的 16 3例住院确诊为原发性痛风患者的临床资料。所有患者都常规检查血尿酸、2 4h尿尿酸、血胆固醇、甘油三脂、空腹血糖、餐后 2h血糖、心电图、X 全胸片及关节片等 ,并进行综合分析。采用 χ2 检验。结果 16 3例原发性痛风患者中 12 2例有伴发病 ,占 74.8% ,其中有 2种以上伴发病 80例占 5 6 .6 %。伴发冠心病 5 8例占 35 .6 % ,高血压病 87例占 5 3 .4% ,高脂血症 82例占 5 0 .3% ,糖尿病 37例占 2 2 .7%。痛风伴发病与年龄呈正相关 ,年龄越大 ,伴发病越多。结论作为嘌呤代谢紊乱的原发性痛风是冠心病、高血压病、高脂血症、糖尿病的恶化因素 ,对人类健康是一个潜在威胁 ,必须引起重视。
Objective To study the relationship between primary gout and concomitant diseases (coronary heart disease, hypertension, hyperlipidemia and diabetes). Methods The clinical data of 163 patients diagnosed as primary gout in hospital from January 1989 to March 1998 were summarized. All patients routine examination of uric acid, 24 h urine uric acid, blood cholesterol, triglycerides, fasting blood glucose, 2 h postprandial blood glucose, ECG, X full chest and joint films, and a comprehensive analysis. Using χ2 test. Results Among the 163 cases of primary gout, 12 2 cases were associated with the disease, accounting for 74.8%. Among them, 80 cases (56.6%) had more than 2 cases. 58 cases with coronary heart disease accounted for 35.6%, 87 cases of hypertension accounted for 53.4%, 82 cases of hyperlipidemia accounted for 50.3%, 37 cases of diabetes accounted for 22.7%. Gout with the incidence was positively correlated with age, the older, with more disease. Conclusion As the primary gout of purine metabolic disorder, it is a risk factor of coronary heart disease, hypertension, hyperlipidemia and diabetes. It is a potential threat to human health and must be taken seriously.