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目的:探讨潜阳化瘀方对有色家免视网膜静脉阻塞血管内皮生长因子(VEGF)表达的影响。方法:将48只家兔随机分为A(空白组)、B(模型组)、C(复方血栓通组)、D(潜阳化瘀方组)四组,每组12只。以氩激光照射视网膜静脉从而阻塞主干静脉的方法造模,分别于造模当天、造模后1、14、28 d进行眼底照相及眼底荧光素血管造影(FFA)检测,并取眼球作病理切片,对VEGF进行计算机图像测定分析并比较。结果:与模型组相比,潜阳化瘀方可显著降低视网膜上的VEGF形成(P<0.05)。结论:潜阳化瘀方能抑制家兔视网膜静脉阻塞的新生血管形成。
Objective: To investigate the effect of QianYang Huayu Recipe on the expression of vascular endothelial growth factor (VEGF) in retinal vein occlusion of non-ferrous home. Methods: 48 rabbits were randomly divided into four groups: A (blank group), B (model group), C (compound Xueshuantong group) and D (Qianyanghuayu group), with 12 rats in each group. The method of modeling the trunk vein by irradiating the retinal vein with Argon laser to occlude the trunk vein was used for fundus photography and fundus fluorescein angiography (FFA) on the day of modeling and 1, 14 and 28 days after modeling, , The computer image analysis of VEGF analysis and comparison. Results: Compared with the model group, Qianyang Huayu Recipe could significantly reduce the VEGF formation on the retina (P <0.05). Conclusion: Qianyang Huayu prescription can inhibit neovascularization of retinal vein occlusion in rabbits.