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与IgG的Fc段结合的Fcγ受体(FcγR)在体液免疫与细胞免疫的联系中起重要作用。人类的FcγRⅡ包括兴奋性的FcγRⅡA和FcγRⅡC,以及抑制性的FcγRⅡB。大量研究表明,FcγRⅡ的表达和基因多态性与多种自身免疫性疾病的易感性密切相关,如SLE类风湿性关节炎及特发性血小板减少性紫癜等,而针对FcγR的靶向治疗将成为治疗自身免疫性疾病的重要手段。
The Fcγ receptor (FcγR), which binds to the Fc portion of IgG, plays an important role in the connection of humoral and cellular immunity. Human FcγRII includes excitatory FcγRIIA and FcγRIIC, and inhibitory FcγRIIB. A large number of studies have shown that the expression and genetic polymorphisms of FcγRⅡ are closely related to the susceptibility to various autoimmune diseases such as SLE rheumatoid arthritis and idiopathic thrombocytopenic purpura. The targeted therapy targeting FcγR Become an important means of treatment of autoimmune diseases.