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目的探究全身化疗联合纤维支气管镜介入治疗耐多药肺结核的临床疗效。方法选取2012年4月—2014年1月南丰县人民医院收治的100例耐多药肺结核患者,随机分为对照组和观察组,各50例。对照组给予全身化疗治疗,观察组在对照组的基础上给予纤支镜介入治疗,比较两组患者的痰菌转阴率、病灶吸收和空洞闭合情况。结果观察组治疗3、6、12、15个月的痰菌转阴率高于对照组,差异有统计学意义(P<0.05)。观察组病灶吸收和空洞闭合情况均优于对照组,差异有统计学意义(P<0.05)。结论全身化疗联合纤支镜介入治疗耐多药肺结核的疗效确切。
Objective To investigate the clinical effect of systemic chemotherapy combined with bronchofibroscopy in the treatment of multidrug-resistant pulmonary tuberculosis. Methods From April 2012 to January 2014, 100 patients with multi-drug resistant pulmonary tuberculosis in Nanfeng County People’s Hospital were randomly divided into control group and observation group, with 50 cases each. The control group was treated with systemic chemotherapy. The observation group was given bronchofibroscope interventional therapy on the basis of the control group. The sputum negative rate, the absorption of the lesion and the cavity closure were compared between the two groups. Results The negative rate of sputum bacteria in the observation group at 3, 6, 12 and 15 months was higher than that in the control group (P <0.05). The observation group had better absorption and void closure than the control group, with significant difference (P <0.05). Conclusion The effect of systemic chemotherapy combined with bronchoscopic interventional treatment of multidrug-resistant pulmonary tuberculosis is accurate.