高密度脂蛋白 (HDL)及其载脂蛋白具有抗动脉粥样硬化作用 ;这种血管保护作用主要是通过胆固醇逆转运来实现的。胆固醇外流是胆固醇逆转运的第一步 ,目前已明确ATP结合盒转运子A1 (ABCA1 )在胆固醇外流方面起关键作用。有关ABCA1的作用机制、表达调控和相互作用等方面的研究 ,近年来取得了很大的进展。对ABCA1的深入研究有利于进一步阐明脂质代谢过程 ,为防治脂质异常血症和动脉粥样硬化提供新思路和新手段 High-density lipoprotein (HDL) and its apolipoprotein have anti-atherosclerotic effects; this vascular protective effect is mainly achieved by cholesterol reverse transport. Cholesterol efflux is the first step in the reverse cholesterol transport and it has now been clarified that ATP-binding cassette transporter A1 (ABCA1) plays a key role in cholesterol efflux. In recent years, great progress has been made in the research of ABCA1 mechanism of action, regulation of expression and interaction. In-depth study of ABCA1 is conducive to further elucidate the lipid metabolism process, to provide new ideas and new methods for the prevention and treatment of lipid abnormalities and atherosclerosis