本文所用曼氏血吸虫敏感株为波多黎谷株。抗羟蒽酮的虫株系在实验室内保存的Baltimore株,用前以1次肌注羟蒽酮800mg/kg选育。经在3代虫重复选育后,与对羟蒽酮敏感的虫株进行杂交。另一抗性株是从感染对羟葸酮敏感的曼氏血吸虫的小鼠,用羟蒽酮800mg/kg×1治疗后,选取残存有成对成虫的小鼠肝卵孵化的毛蚴,感染双脐螺后再用逸出的尾蚴感染小鼠,用羟葸酮重复治疗培育的抗性株。从感染抗性株和敏感株的杂交的血吸虫 The Schistosoma mansoni susceptible strain used in this article is Puerto Rico. Anti-oxetanone strains were maintained in laboratory Baltimore strain, with 1 intramuscular injection of hydroxyanthrone 800mg / kg before breeding. After three generations of insects repeated breeding, with the paraoxon-sensitive strains of hybrids. Another resistant strain was mice infected with Schistosoma japonicum Schistosoma japonicum and treated with oxetanone at a dose of 800 mg / kg x 1. The miracidia hatching in the eggs of mouse pawns remaining in pairs were selected and infected with double Mucuna was then infected with escaped cercariae, and the resistant strains were repeatedly treated with oxycodone. Schistosoma japonicum from hybrids infected with resistant and susceptible strains