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采用血管灌流大鼠离休胃模型，探讨生长抑素对胃运动的影响。结果表明：（１）生长抑素能明显抑制胃窦自发和胃动素兴奋的胃运动；（２）生长抑素可抑制离休胃内源性胃泌素释放；（３）抗生长抑素血清和前列腺素合成酶抑制剂消炎痛可阻断生长抑素对胃窦运动的抑制作用。上述结果提示：生长抑素的抑制作用除通过直接作用于生长抑素受体外，还可能通过胃窦局部前列腺素介导来抑制胃的运动。
Effects of somatostatin on gastric motility in rats after reperfusion of gastric perfusion model. The results showed that: (1) somatostatin can significantly inhibit spontaneous gastric motility and motilin excited gastric motility; (2) somatostatin can inhibit the release of endogenous gastric gastrin; (3) anti-somatostatin serum And prostaglandin synthase inhibitor indomethacin can block somatostatin inhibition of gastric motility. The above results suggest that the inhibitory effect of somatostatin may inhibit the gastric motility through the local prostaglandin mediated by gastric antrum in addition to acting directly on the somatostatin receptor.