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目的:探讨胎儿宫内发育迟缓(IUGR)与血浆肾上腺髓质素(ADM)和胎盘异铁蛋白(PLF)的关系,为临床防治IUGR提供新思路。方法:根据随访妊娠结局IUGR组30例、正常组30例,晚孕早期用ELISA法检测血浆ADM水平,化学分析法测定血浆PLF水平。结果:与正常组比较,IUGR组血浆ADM水平明显升高、PLF水平明显降低,差异具有统计学意义(P<0.01)。IUGR者血浆ADM水平与PLF显著负相关(r=-0.543,P<0.01)。结论:血浆ADM水平升高和PLF水平降低与IUGR的发生密切相关。
Objective: To investigate the relationship between intrauterine growth retardation (IUGR) and plasma adrenomedullin (ADM) and placental isoferritin (PLF), and to provide new ideas for the prevention and treatment of IUGR. Methods: According to the outcome of follow-up, 30 cases of IUGR group and 30 cases of normal pregnancy group were enrolled in this study. Plasma ADM level was measured by ELISA and plasma PLF level by chemical analysis. Results: Compared with the normal group, plasma ADM levels in IUGR group were significantly increased and PLF level was significantly lower (P <0.01). Plasma ADM levels in IUGR patients were negatively correlated with PLF (r = -0.543, P <0.01). Conclusion: The increase of plasma ADM level and the decrease of PLF level are closely related to the occurrence of IUGR.