随着职业卫生和毒理学研究的进展,许多学者都在致力于寻找一些毒物接触指标,以敏感地反映毒物对机体的损害作用,并阐明毒物的毒作用机制,进而为生物监测和职业人群的健康监护,提供科学依据。血红素及血红蛋白合成的详细过程已经比较明了,而且人体内几乎所有细胞都有合成血红素的能力。红细胞合成的血红素主要用于合成血红蛋白,而肝脏内合成的血红素则主要用于合成各种血红素蛋白,特别是细胞色素P-450。因此血红素合成异常,不但会影响血红蛋白、肌红蛋白、细胞色素、过氧化氢酶的合成,甚至前列腺素的合成以及平滑肌与苷酸环化酶的功能也会受到影响,这就提示了这一合成通路出现的异常有作为一些毒物接触指 With the advancement of occupational health and toxicology research, many scholars are devoting themselves to searching for indicators of toxicological exposure to reflect the toxic effects on the organism sensitively and to elucidate the toxic mechanism of toxicological effects, and thus to provide guidance to biological monitoring and occupational groups Health care, to provide a scientific basis. The detailed process of hemoglobin and hemoglobin synthesis has been relatively clear, and almost all cells in the human body have the ability to synthesize heme. The hemoglobin synthesized by erythrocytes is mainly used for the synthesis of hemoglobin, while the hemoglobin synthesized in the liver is mainly used for the synthesis of various heme proteins, especially the cytochrome P-450. Therefore, the abnormal synthesis of heme will not only affect the hemoglobin, myoglobin, cytochrome, catalase synthesis, and even the synthesis of prostaglandins and smooth muscle enzymes and cyclases will also be affected, suggesting that this An anomaly in a synthetic pathway has been identified as some poisons