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目的：探讨西沙必利对胃排空延缓并伴有胃节律障碍的作用。方法：６０例以胃排空延缓为特征，体表胃电图（ＥＧＧ）示胃节律紊乱的病人，均分为给药组３０例（男性１１例，女性１９例），年龄４４±ｓ１１ａ，病程４．８±１．５ｍｏ，给予西沙必利１０ｍｇ，餐前１５ｍｉｎ，ｐｏ，ｔｉｄ，３ｗｋ为一个疗程；对照组３０例（男性１２例，女性１８例），年龄４６±１０ａ，病程４．９±１．２ｍｏ，用安慰剂（淀粉），给药方法同治疗组。结果：疗程结束后，治疗组病人的症状完全缓解，ＥＧＧ示胃节律正常２１例；症状好转，ＥＧＧ示胃节律正常７例；症状未缓解，ＥＧＧ示胃节律障碍２例。总有效率治疗组９３％；对照组１３％。结论：西沙必利治疗胃排空延缓伴有胃节律障碍是有效的。
Objective: To investigate the effect of cisapride on gastric emptying accompanied with gastric dysrhythmia. Methods: Sixty patients were characterized by delayed gastric emptying. EGG showed gastric dysrhythmia in 30 patients (11 males and 19 females), age 44 ± s11a, Duration of 4.8 ± 1.5mo, given cisapride 10mg, 15min before meals, po, tid, 3wk for a course of treatment; control group of 30 patients (12 males and 18 females), age 46 ± 10a, duration 4. 9 ± 1.2mo, placebo (starch), administration method with the treatment group. Results: At the end of the course of treatment, the symptoms in the treatment group were completely relieved. EGG showed normal gastric rhythm in 21 cases. The symptoms were improved. EGG showed normal gastric rhythm in 7 cases. The symptoms were not relieved. EGG showed gastric rhythm disturbance in 2 cases. The total effective treatment group 93%; control group 13%. CONCLUSIONS: Cisapride is effective in treating delayed gastric emptying with gastric disorders.