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To reduce the first-pass effect and increase the targeting of ozagrel(OZ),the ozagrel-magnetoliposomes(OZ-MLs)were prepared in this study.Here,we described the preparation and characterization of OZ-MLs.It had a diameter of around 0.2 μm.To prevent the aggregation of particles,the magnetite was treated with a surfactant,resulting in a stable ferrofluid suspension.The cumulative release of OZ from OZ-MLs could be up to 64.5 % in 30 min in vitro under AC-magnetic field.However,it was only 24.0 % for OZ-MLs without AC-magnetic field.