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目的:探讨胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)在宫颈鳞状细胞癌组织中的表达、临床病理意义及其与预后的关系。方法:应用免疫组织化学EnVisionTM法分别检测慢性宫颈炎30例、宫颈上皮内瘤变35例及宫颈鳞状细胞癌75例组织中IGF-1的表达情况。结果:IGF-1表达阳性率在慢性宫颈炎组织中为3.33%,宫颈上皮内瘤变组织中为37.14%,宫颈鳞状细胞癌组织中为57.33%,3组之间差异有统计学意义(χ2=26.13,P<0.01)。在宫颈鳞状细胞癌相关临床病理因素中,IGF-1的表达与肿瘤大小、淋巴结转移、远处脏器转移、FIGO分期有关,差异均有统计学意义(均P<0.05);但与年龄、组织学类型、增值指数(Ki-67)、P53无关,差异无统计学意义(P>0.05)。生存分析显示,IGF-1蛋白阳性患者生存率明显低于阴性患者,差异有统计学意义(χ2=4.42,P<0.05)。结论:在不同的宫颈病变中,IGF-1的表达随着病变的升级而逐步升高,这表明IGF-1在一定程度上参与了宫颈病变的演变,同时也预示着患者预后差。
Objective: To investigate the expression of insulin-like growth factor-1 (IGF-1) in cervical squamous cell carcinoma and its clinicopathological significance and prognosis. Methods: The expression of IGF-1 in 30 cases of chronic cervicitis, 35 cases of cervical intraepithelial neoplasia and 75 cases of cervical squamous cell carcinoma were detected by EnVisionTM immunohistochemistry. Results: The positive rate of IGF-1 expression was 3.33% in chronic cervicitis tissues, 37.14% in cervical intraepithelial neoplasia tissues and 57.33% in cervical squamous cell carcinoma tissues. The difference between the three groups was statistically significant ( χ2 = 26.13, P <0.01). The expression of IGF-1 in cervical squamous cell carcinoma correlated with tumor size, lymph node metastasis, distant organ metastasis, FIGO stage, the differences were statistically significant (all P <0.05), but with age , Histological type, value-added index (Ki-67), P53 had no difference, the difference was not statistically significant (P> 0.05). Survival analysis showed that the survival rate of IGF-1 positive patients was significantly lower than that of negative patients (χ2 = 4.42, P <0.05). CONCLUSION: In different cervical lesions, the expression of IGF-1 gradually increases with the escalation of lesions, indicating that IGF-1 is involved in the development of cervical lesions to a certain extent and also indicates the poor prognosis of patients.