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EGR 1是一具有 3个锌指结构的转录因子。其基因Egr 1的转录和表达受多种因素调控。EGR 1能与许多基因的启动子区类似或相同于SP1和WT1的DNA序列结合 ,与WT1或SP1竞争或协同调控目的基因的转录。Egr 1在多种恶性肿瘤细胞中转录及表达减低或缺失 ,这是由于这些细胞缺乏转录和表达潜力。外源高表达EGR 1能抑制一些肿瘤的生长和恶性表型 ,其作用与下调bcl 2及激活TGFβ1 ,FN ,p2 1和FAK的表达有关。故认为该基因是一具基因治疗价值的Ⅱ类抑癌基因。Egr 1基因启动子的放射可诱导性也被用于一些肿瘤的治疗研究。
EGR 1 is a transcription factor with three zinc finger structures. The transcription and expression of its gene Egr 1 is regulated by many factors. EGR 1 can bind to the DNA sequences of SP1 and WT1 similar to or identical to the promoter regions of many genes, and compete with WT1 or SP1 to regulate the transcription of the target gene. Egr 1 is transcribed and reduced or deleted in many malignant cells due to the lack of transcription and expression potential of these cells. Exogenous high expression of EGR 1 can inhibit the growth and malignant phenotype of some tumors. Its role is related to down-regulation of bcl 2 and activation of TGFβ1, FN, p21 and FAK expression. It is considered that this gene is a gene therapy type II tumor suppressor gene. The radioinducibility of the Egr 1 gene promoter has also been used in the treatment of some tumors.