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目的调查临沧地区H型高血压流行病学特点及探讨叶酸片干预治疗对H型高血压患者同型半胱氨酸水平的影响.方法收集原发性高血压患者共292例,调查其H型高血压的流行病学特点;将其中的133例H型高血压患者随机分为2组,实验组72例,对照组61例,2组均给予相同降压药物治疗,其中实验组在降压药物治疗基础上,再给予口服叶酸片5 mg,qd,检测3个月后2组患者同型半胱氨酸水平的变化情况.结果得到临沧地区H型高血压的流行病学特点;实验组给予叶酸片干预治疗3个月后,同型半胱氨酸水平下降明显(P<0.05),对照组下降不明显.结论叶酸片干预治疗3个月,可以很明显降低H型高血压患者同型半胱氨酸水平值,值得临床推广应用.
Objective To investigate the epidemiological characteristics of Hypertension in Lincang region and to explore the effect of folic acid tablets intervention on the level of homocysteine in patients with Hypertension.Methods A total of 292 patients with essential hypertension were collected and their H type 133 patients with H-type hypertension were randomly divided into two groups, 72 cases in the experimental group and 61 cases in the control group. The two groups were given the same antihypertensive drugs, in which the experimental group was treated with antihypertensive Based on the drug treatment, and then given oral folic acid tablets 5 mg, qd, 3 months after the detection of homocysteine levels changes in two groups.Results Hp hypertension in Lincang epidemiological characteristics of the experimental group The level of homocysteine decreased significantly (P <0.05) 3 months after the intervention of folic acid tablets, but the decrease of the control group was not obvious.Conclusion The folic acid tablets intervention for 3 months can significantly reduce the homocysteine levels in patients with Hypertension Cystine levels, worthy of clinical application.