Taking inspiration from nature,the biomimetic concept has been integrated into drug delivery systems in cancer therapy.Disguised with cell membranes,the nanoparticles can acquire various functions of natural cells.The cell membrane-coating technology has pushed the limits of common nano-systems (fast elimination in circulation) to more effectively navigate within the body.Moreover,because of the various functional molecules on the surface,cell membrane-based nanoparticles (CMBNPs) are capable of interacting with the complex biological microenvironment of the tumor.Various sources of cell membranes have been explored to camouflage CMBNPs and different tumor-targeting strategies have been developed to enhance the anti-tumor drug delivery therapy.In this review article we highlight the most recent advances in CMBNP-based cancer targeting systems and address the challenges and opportunities in this field.