论文部分内容阅读
目的:评价国产与进口噻氯匹定(TCP)对60例心脑血管疾病伴有血小板聚集率高的患者血液流变学的影响.方法:采用多中心、开放平行对照.结果:两药均能显著降低血小板聚集率、纤维蛋白原、全血比粘度、血浆比粘度(P<0.01).两药对血小板聚集率、纤维蛋白原、全血比粘度、血浆比粘度在治疗前后的差值无统计学差异(P>0.05).两组治疗后出血、凝血时间比治疗前均有延长,但无统计学差异(P>0.05),两组治疗前后出血、凝血时间的差值经统计学处理无显著差异(P>0.05).国产和进口TCP不良反应发生率分别为22.5%、30%,两者无显著差异.结论:国产与进口TCP同样具有较好的抗血小板聚集作用,且不良反应少,适用于高血小板聚集率的治疗,可用来预防血栓性疾病.
Objective: To evaluate the effect of domestic and imported timolipid (TCP) on the hemorheology in 60 patients with cardiovascular and cerebrovascular diseases with high platelet aggregation rate.Methods: Multi-center and open parallel control were used.Results: (P <0.01). The difference of platelet aggregation rate, fibrinogen, whole blood specific viscosity and plasma specific viscosity between two drugs before and after treatment can significantly reduce the platelet aggregation rate, fibrinogen, whole blood specific viscosity and plasma specific viscosity (P> 0.05) .After treatment, the hemorrhage and coagulation time in both groups were longer than those before treatment, but there was no significant difference (P> 0.05). The differences of hemorrhage and coagulation time before and after treatment were statistically (P> 0.05) .The incidence rates of domestic and imported TCP adverse reactions were 22.5% and 30%, respectively, and there was no significant difference between the two methods.Conclusion: Domestic and imported TCP also have good anti-platelet aggregation effect, Less reaction, suitable for the treatment of high platelet aggregation rate, can be used to prevent thrombotic diseases.