例1 女,36岁,于1998年5月6日入院,诊断为“肾病综合征”。由于并发肺部感染予青霉素治疗效果不佳,改用头孢哌酮钠静脉滴注(2g/次,2次/d)。用药24h后皮肤出现散在红色斑丘疹,遂后扩大并连成片,且逐渐形成水疱,经过积极抗过敏及先后换用红霉素、氧哌嗪青霉素、氧氟沙星等抗生素治疗,效果均不明显,后继发败血症,于1个月后死于肾功能衰竭。 例2 女,64岁,于2001年2月23日入院,诊断为“脑梗死”。1周后体温上升,胸透示右侧肺部有片状阴影,考虑并发肺部感染。予头孢哌酮钠静脉滴注(2g/次,2次/d)。第1 Example 1 Female, 36 years old, was admitted on May 6, 1998 and was diagnosed as “nephrotic syndrome.” Cefoperazone sodium infusion (2g / time, 2 times / d) was used because of the poor efficacy of concurrent pulmonary infection to penicillin. After treatment for 24h, the skin appeared scattered red rash, and then expanded and even into pieces, and gradually formed blisters, after active anti-allergic and have switched to erythromycin, piperacillin penicillin, ofloxacin and other antibiotics, the effect was Obvious, secondary septicemia, died of renal failure after 1 month. Example 2 Female, 64 years old, admitted to hospital on February 23, 2001 and diagnosed as “cerebral infarction.” After 1 week the body temperature rises, the chest shows the right side of the lung shadow flake, consider concurrent pulmonary infection. Cefoperazone sodium intravenous infusion (2g / times, 2 times / d). First