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目的 :在小鼠实体瘤模型中研究贫血对化疗疗效的影响。方法 :用单次剂量的卡铂 (5 0mg/kg)静推造成Hb较长时间的降低。在另一组中 ,用卡铂前 7天始予rHuEPO(1 0 0 0IU/kg)皮下注射 3次 /周预防贫血的发展。两组均于卡铂用后的第 4天自小鼠的右侧腋部皮下植入肿瘤 (S1 80 小鼠肉瘤 )。植入肿瘤后的第 5天用单次剂量的CTX(6 0mg/kg)静脉注射。结果 :rHuEPO可以防治化疗所致的贫血。化疗后可见到肿瘤生长受到抑制 ,随后肿瘤又再生长。贫血组的肿瘤生长延缓时间要短于非贫血组 (6 3天比 9 3天 ) ,被纠正的贫血组的肿瘤生长延迟时间与对照组大致相仿 (9 3天 )。结论 :贫血可导致肿瘤化疗疗效的降低 ,其机制可能与肿瘤组织的低氧供有关。而通过rHuEPO纠正贫血可望提高化疗的疗效
Objective: To study the effect of anemia on the curative effect of chemotherapy in the mouse solid tumor model. Methods: A single dose of carboplatin (50 mg / kg) was used to push Hb for a longer period of time. In the other group, the development of anemia was prevented by subcutaneous injection of rHuEPO (10 000 IU / kg) three times a week for 7 days prior to carboplatin. Both groups were subcutaneously implanted with tumor (S180 mouse sarcoma) on the right axilla of the mice on day 4 after carboplatin administration. On day 5 after tumor implantation, a single dose of CTX (60 mg / kg) was injected intravenously. Results: rHuEPO can prevent chemotherapy-induced anemia. Chemotherapy can be seen after the inhibition of tumor growth, followed by tumor growth again. Tumor growth delay was shorter in the anemia group than in the non-anemia group (63 days vs 93 days), and the tumor growth delay in the anemia group was similar to that in the control group (93 days). Conclusion: Anemia can lead to the decrease of the curative effect of tumor chemotherapy. The mechanism may be related to the hypoxia supply of tumor tissue. Anemia through rHuEPO is expected to improve the efficacy of chemotherapy