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2型糖尿病以胰岛素靶组织的胰岛素抵抗为特征,在2型糖尿患者群中有80%～85%的个体有肥胖症。抵抗素(Resistin)又称为脂肪组织特异性的分泌因子(ADSF),是新近在鼠类脂肪组织中发现的由脂肪细胞特异性分泌的多肽类激素,在鼠类可以引起胰岛素抵抗,肥胖小鼠体内的抵抗素水平升高,因而被认为是连结肥胖和2型糖尿病之间的一个中介分子。抵抗素最初在小鼠的白色脂肪组织中被发现,近来很多研究在人类的许多组织中发现也有抵抗素的表达,并对其结构、功能等进行了一系列的研究。本文针对抵抗素与肥胖和2型糖尿病间关系的研究作一综述。
Type 2 diabetes is characterized by insulin resistance in insulin target tissues and 80% to 85% of individuals with type 2 diabetes have obesity. Resistin, also known as adipose tissue-specific secretory factor (ADSF), is a polypeptide hormone newly secreted by adipocytes, found in murine adipose tissue. It can cause insulin resistance in mice and obesity is small Increased levels of resistin in the mouse are therefore thought to be an intermediary between obesity and type 2 diabetes. Resistin was originally found in mouse white adipose tissue. Recently, many studies have found that there are many resistin expression in many tissues of human and a series of studies on its structure, function and so on. This article reviews the relationship between resistin and obesity and type 2 diabetes mellitus.