抗菌素致过敏休克已屡見不鲜,以青、鏈霉素所致者居多,四环素族过敏者多为胃腸刺激症状及皮疹等,严重过敏休克尚未提及。現将本院遇到四环素族过敏休克两例报告如下: 例1,高××,男,26岁,1965年3月18日下午4时因右下腹疼、发冷、发烧七八天,經当地医生用青霉素油、水剂,及鏈霉素等治疗无效来本院。初步印象为急性闌尾炎穿孔,局限性腹膜炎。限于本院条件不能立即手术,故先行保守治疗。患者系西药售貨員,主动提出改用四环素而后轉院手术。于当日下午5时将盐酸四环素50万单位,溶于50％葡萄糖60毫升内,以每分钟10000单位速度緩緩靜脉注入。注入約50毫升时,患者感咽部烧灼,发干,出气发蹩。立即停止注入,此时脉搏明显不整,期外收縮,心率极慢。約半分钟后脉搏消失,患者自头部至全身青紫,意识丧失,呼吸、心跳停止。立即行胸外心脏按摩,人工呼吸,心前区肌肉注射盐酸腎上腺素1毫克,靜脉注入尼克拉明1.5毫克,針刺十宣、人中、兌端,約1分多钟后心跳恢复,自动呼吸,紫绀渐渐缓解,意识恢复,四肢冷汗自流。追訊患者于半年前曾口服过四 Anaphylactic shock caused by antibiotics is not uncommon. Mostly caused by cyanine and streptomycin, most people with tetracycline allergy are gastrointestinal irritation symptoms and skin rashes. However, severe allergic shock has not been mentioned yet. Now the hospital encountered tetracycline allergic shock two cases are reported as follows: Example 1, high × ×, male, 26 years old, at 18:00 on March 18, 1965 due to right lower quadrant pain, chills, fever seven or eight days, Local doctors with penicillin oil, water, and streptomycin treatment invalid to our hospital. The initial impression of acute appendicitis perforation, localized peritonitis. Limited to the hospital conditions can not be surgery immediately, so first conservative treatment. Department of Western medicine salesman, took the initiative to switch to tetracycline and transfer surgery. At 5:00 pm on the same day tetracycline hydrochloride 500,000 units, dissolved in 50% glucose 60 ml, the slow intravenous infusion of 10,000 units per minute speed. Injection of about 50 ml, the patient sore throat, dry, bad hair. Immediately stop injection, then the pulse was not the whole period, period contraction, the heart rate is very slow. About half a minute after the pulse disappeared, the patient from the head to the body bruising, loss of consciousness, breathing, cardiac arrest. Immediate chest cardiac massage, artificial respiration, preclinical intramuscular injection of 1 mg of epinephrine hydrochloride, intravenous injection of niacin 1.5 mg, acupuncture ten declared, people, against the end, about 1 minute after the heartbeat recovery, automatic Breathing, cyanosis gradually eased, recovery of consciousness, limb cold sweat. Chase the patient had oral four months ago