论文部分内容阅读
目的 探讨直肠癌Duke’sB2 ,C1,C2 期术后放射治疗的价值。方法 我院在 1992年 1月至1998年 3月期间收治 10 5例Duke’sB2 ,C1,C2 期直肠癌患者 ,将其随机分为两组 :单纯手术组 5 5例 ,术后放疗组 5 0例。采用60 Co体外等中心放疗 ,瘤床DT 5 0～ 5 5Gy/ 5～ 6周 ,亚临床病灶DT 4 0Gy/ 4周。 结果 术后放疗组和单纯手术组 5年生存率B2 ,C1,C2 期分别为 :81 8%、6 0 0 % (P >0 0 5 ) ;6 1 5 % ,32 5 % (P <0 0 5 ) ;38 7% ,11 7% (P <0 0 5 )。 5年局部复发率 :术后放疗组和单纯手术组B2 ,C1,C2 期分别为 18 2 % ,33 3% (P >0 0 5 ) ;17 4 % ,6 4 0 % (P <0 0 1) ;2 5 0 % ,6 6 7% (P <0 .0 1)。远处转移率 :术后放疗组 10 0 % ,单纯手术组 2 7 3% (P >0 .0 5 )。结论 Duke’sB2 ,C期直肠癌根治术后根治性放疗可以提高长期生存率 ,降低局部复发率
Objective To investigate the value of postoperative radiotherapy for Dukes’sB2, C1 and C2 rectal cancer. Methods A total of 105 patients with Dukes’sB2, C1 and C2 rectal cancer were treated in our hospital from January 1992 to March 1998. They were randomly divided into two groups: 55 cases in the simple operation group and 5 cases in the postoperative radiotherapy group 0 cases. With 60Co in vitro isocontinental radiotherapy, tumor bed DT 5 0 ~ 5 5Gy / 5 ~ 6 weeks, sub-clinical lesions DT 4 0Gy / 4 weeks. Results The 5-year survival rates of B2, C1 and C2 in the postoperative radiotherapy group and the simple operation group were 81 8%, 60 0% (P 0 05), 61 5%, 32 5% (P 0 0 5); 38 7%, 11 7% (P <0 05). The local recurrence rate at 5 years was 18 2%, 33 3% (P 0 05), 17 4%, 64 0% (P 0 0) in the postoperative radiotherapy group and the surgery alone group 1); 2 0%, 6 6 7% (P <0 01). The distant metastasis rate was 100% in the postoperative radiotherapy group and 27.3% in the simple operation group (P> 0.05). Conclusions Radical radiotherapy after radical resection of Dukes’sB2, C can improve the long-term survival rate and reduce the local recurrence rate