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1从现代医学角度分析足细胞与神经元的相似之处蛋白尿是肾脏疾病的关键标志物和判断预后的重要指标,探索其形成的分子机制能够为研发治疗蛋白尿的新型药物提供可能的新思路、新靶点。足细胞已成为研究蛋白尿形成机制的热点,越来越多的实验数据表明,足细胞与神经元有诸多相似之处。1.1形态结构在形态结构上,神经元与足细胞均有复杂分枝突起结构,是终末分化细胞,两者在细胞突起形成过程中均有微管细胞骨架、中间丝以及肌动蛋白纤维,并且形
1 Analysis of similarities between podocytes and neurons from the perspective of modern medicine Proteinuria is a key marker of kidney disease and an important indicator of prognosis. To explore the molecular mechanism of its formation may provide new possibilities for the development of new drugs for the treatment of proteinuria Train of thought, a new target. Podocytes have become a hot spot for studying the mechanism of proteinuria. More and more experimental data show that there are many similarities between podocytes and neurons. 1.1 Morphological structure Morphology and structure, neurons and podocytes have complex branched protruding structure is terminal differentiated cells, both in the process of cell protrusion have a microtubule cytoskeleton, intermediate filaments and actin fibers, And shape