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目的 探讨肺癌CT动态增强特性与微血管密度 (MVD)关系。方法 收集经手术病理证实肺癌病例 3 3例。均做了CT动态增强扫描 ,获得病灶强化起始时间 (ST)、峰值时间 (PT)、强化回落时间 (DT)及强化峰值 (PH)。取手术切除标本 2 0例作抗CD3 4 单抗免疫组织化学染色 ,计数MVD。对 2 0例支气管肺癌PH与MVD作相关分析 ,并分别对腺癌及鳞癌两组MVD及ST、PT、DT、PH作统计学检验。结果 肺癌PH与MVD呈显著正相关 (P <0 .0 1) ,腺癌组MVD明显高于鳞癌组 (P <0 .0 1) ,腺癌组PT小于鳞癌组 (P <0 .0 5 ) ,两组PH、ST、DT无统计学差异 (P均 >0 .0 5 )。结论 CT动态增强特性与肺癌MVD具有相关性 ,并可反映肺癌不同组织学类型
Objective To investigate the relationship between CT dynamic enhancement and microvessel density (MVD) in lung cancer. Methods Thirty-three patients with lung cancer confirmed by surgery and pathology were collected. CT dynamic enhanced scans were performed to obtain focal enhancement initiation time (ST), peak time (PT), enhanced fallback time (DT), and enhancement peak (PH). Surgical resection specimens were performed in 20 cases of anti-CD34 monoclonal antibody immunohistochemical staining, and MVD was counted. The correlation between PH and MVD in 20 patients with bronchial lung cancer was analyzed. MVD and ST, PT, DT, and PH of adenocarcinoma and squamous cell carcinoma were statistically examined. Results There was a significant positive correlation between PH and MVD in lung cancer (P < 0.01), MVD in adenocarcinoma was significantly higher than in squamous cell carcinoma (P <0.01), and PT in adenocarcinoma was less than squamous cell carcinoma (P <0. 05) There was no statistical difference in PH, ST and DT between the two groups (all P > 0. 05). Conclusion The dynamic characteristics of CT are correlated with MVD in lung cancer and reflect different histological types of lung cancer.