Objective:To compare the clinical efficacy of oral dydrogesterone with both vaginal progesterone suppository and intramuscularly injected progesterone for luteal phase support in frozen-thawed embryo transfer (FET) artificial cycles.Methods: In this pilot single-blind randomized controlled trial, 180 infertile women undergoing FET cycles were recruited and allocated into three equal groups named as group A receiving 50 mg intramuscular progesterone ampules twice daily, group B receiving oral dydrogesterone 20 mg twice daily, and group C receiving 400 mg intravaginal progesterone suppository twice daily. Clinical pregnancy rates were the primary outcome. Abortion, ectopic pregnancy and live birth rates were the secondary outcome.Results:Pregnancy and live birth rates were comparable for all the three groups (P=0.466 and 0.367 respectively). Miscarriage rates were not significantly different among groups (P=0.487). All the resulting pregnancies for each group were intrauterine with none of them associated with ectopic origin.Conclusion:Given that oral dydrogesterone seems to be more accepted by patients in terms of ease of use, lower cost and satisfaction, it could be prescribed for luteal phase support in artificial FET cycles as effective as either intramuscular or vaginal supplements.