小肝癌的定义已由<5cm改为≤3cm的肝癌,1983年日本肝癌研究协作组定为≤2cm。所谓亚临床肝癌亦包括小肝癌,但也有部份是无症状甚至不能切除的大肝癌。肿瘤标志血清AFP的检测,对我国所见的肝癌是一种行之有效的诊断方法,但对于<3cm肝癌的筛选价值却不高,日本千叶大学报告阳性率(>200ng/ml)仅9%,在上海为<45.5%。晚近 The definition of small liver cancer has been changed from <5cm to ≤3cm of liver cancer, and in 1983, Japan’s HCC collaborative group was set to ≤2cm. The so-called subclinical liver cancer also includes small liver cancer, but there are some asymptomatic or not resectable large liver cancer. Tumor marker serum AFP detection, liver cancer seen in our country is an effective diagnostic method, but screening for <3cm liver cancer is not high, the Japanese Chiba University reported a positive rate (> 200ng / ml) only 9 %, In Shanghai <45.5%. Late