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目的:探讨DNA-PKcs基因蛋白表达与鼻咽癌(NPC)临床分期、放射治疗敏感性及预后的关系。方法:对107例NPC放疗前鼻咽部组织活检标本,采用免疫组织化学技术检测DNA-PKcs在NPC组织中的表达情况,并分析其表达与NPC的临床分期、放射治疗敏感性及治疗后生存率之间的关系。结果:NPC组织中DNA-PKcs蛋白在细胞核中均有表达,放射治疗肿瘤快速退缩组的表达水平明显低于缓慢退缩组及残留组,P<0.05;但缓慢退缩组与残留组之间的表达差异无统计学意义,P>0.05;不同临床分期和有无颈淋巴结转移的表达水平差异无统计学意义,P>0.05;低表达组(阳性细胞百分率<50%)和高表达组(阳性细胞百分率>50%)生存曲线差异无统计学意义,P>0.05。结论:NPC组织中DNA-PKcs基因蛋白表达水平与患者临床分期、颈淋巴结转移及预后无确切相关性,但有可能作为预测NPC放射治疗敏感性的有效指标。
Objective: To investigate the relationship between the expression of DNA-PKcs protein and clinical stage, radiotherapy sensitivity and prognosis of nasopharyngeal carcinoma (NPC). Methods: Nasopharyngeal biopsy specimens were obtained from 107 NPC patients before radiotherapy. The expression of DNA-PKcs in NPC tissues was detected by immunohistochemical staining. The expression of NPC-NSC was analyzed with the clinical stage, radiosensitivity and post-treatment survival The relationship between rates. Results: The expression of DNA-PKcs protein in NPC tissues was detected in the nucleus, and the expression level of tumor rapidly retreated in the radiotherapy group was significantly lower than that in the retarded group and the residual group (P <0.05). However, the expression of DNA-PKcs protein in the retarded group and the residual group There was no significant difference between the two groups (P> 0.05). There was no significant difference between different clinical stages and the presence or absence of cervical lymph node metastasis (P> 0.05), while the expression of positive cells Percentage> 50%) There was no significant difference in survival curves, P> 0.05. CONCLUSION: The expression of DNA-PKcs in NPC tissue is not correlated with clinical stage, cervical lymph node metastasis and prognosis, but it may be used as an effective index to predict the sensitivity of NPC radiotherapy.