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目的 :探讨吸烟者餐后甘油三酯代谢与血管内皮功能的关系。方法 :30位吸烟者 (吸烟组 )和 2 0位非吸烟者 (非吸烟组 )禁食 12小时后 ,检测空腹肱动脉血流介导的内皮依赖性血管舒张功能 ,随后接受高脂餐饮食 ,于空腹及餐后 2、4、5、7小时测定血清甘油三酯浓度。结果 :吸烟组血流介导的内皮依赖性血管舒张功能显著受损 (P <0 0 0 1) ,餐后 2 ,4,5 ,7小时血清甘油三酯浓度显著升高 ,与非吸烟组比较 ,有显著性差异 (P <0 0 5 ) ,其甘油三酯曲线下面积显著大于非吸烟组 (P <0 0 5 )。内皮依赖性血管舒张功能与甘油三酯曲线下面积呈显著负相关 (r =-0 35 9,P <0 0 5 )。结论 :吸烟者存在餐后甘油三酯代谢障碍 ,它与血管内皮功能失调密切相关
Objective: To investigate the relationship between postprandial triglyceride metabolism and vascular endothelial function in smokers. Methods: Fasting brachial artery-mediated endothelium-dependent vasodilatation was measured in 30 smokers (smoker group) and 20 nonsmokers (nonsmokers) for 12 hours after fasting, followed by high-fat diet Serum triglyceride concentrations were measured at fasting, 2, 4, 5 and 7 hours postprandial. Results: Blood flow-mediated endothelium-dependent vasodilation was significantly impaired in smokers (P <0.01), and serum triglyceride concentrations were significantly increased at 2, 4, 5, 7 hours postprandial (P <0.05). The area under the curve of triglyceride was significantly higher than that of non-smoking group (P <0.05). Endothelium-dependent vasodilation was negatively correlated with the area under the curve of triglycerides (r = -0 35 9, P <0 05). Conclusions: There are postprandial triglyceride metabolic disorders in smokers, which are closely related to endothelial dysfunction