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谷胱甘肽硫转移酶(Glutathione-S-transferase,简称GST)是机体内重要解毒系酶。大多数化学终致癌物是亲电子物质,在GST的催化下与谷胱甘肽结合排出体外,因此GST在化学致癌的解毒机理中起重要作用。丁基羟基茴香醚(BHA),乙氧喹(Ethoxyquin)等抗氧化剂都能增加肝脏GST的活性,研究者们认为此为其防癌作用机制之一。我们用富硒麦芽粉(简称硒麦芽)观察对鼠肝GST活性影响。
Glutathione-S-transferase (GST) is an important detoxification enzyme in the body. Most of the chemical end-cancer carcinogens are electrophiles, which are combined with glutathione and then excreted under the catalysis of GST. Therefore, GST plays an important role in the detoxification mechanism of chemical carcinogenesis. Antioxidants such as butylated hydroxyanisole (BHA) and ethoxyquin all increase hepatic GST activity, which researchers consider as one of the mechanisms of its anti-cancer effects. We use the selenium-enriched malt flour (referred to as selenium malt) observed on the rat liver GST activity.