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一般认为,内源性鸦片样肽对促性腺激素的分泌可能起着紧张性的抑制作用。已报告吗啡可阻断大鼠排卵。吗啡、甲-脑啡肽、亮-脑啡肽、β-内啡肽以及脑啡肽类似物可以减低 LH 的释放。鸦片受体拮抗剂纳洛酮可以对抗或抑制内源性鸦片样物质的作用,或刺激促性腺激素的分泌。最近发现,在正常妇女月经周期的不同时期,点滴纳洛酮对于 LH 分泌的影响不同,这提示,卵巢甾体激素可能调节着下丘脑-垂体系统中内源性鸦片肽的机能活动。本文观察了给绝经后妇女长期服用雌激素前后,点滴纳洛酮对促性腺激素分泌的影响。选择5例51～53岁,闭经三年以上的志愿者进
It is generally believed that the secretion of gonadotropins by endogenous opioid peptides may play a role of tension inhibition. Morphine has been reported to block ovulation in rats. Morphine, alpha-enkephalin, leu-enkephalin, beta-endorphin, and enkephalin analogues can reduce LH release. The opioid receptor antagonist naloxone can counteract or inhibit the action of endogenous opioids or stimulate the secretion of gonadotropins. Recently, it was found that the effects of naloxone on the LH secretion were different at different periods of the menstrual cycle of normal women, suggesting that ovarian steroid hormones may regulate the functional activity of endogenous opioid peptides in the hypothalamus-pituitary system. This article examines the long-term postmenopausal women taking estrogen before and after, the impact of naloxone on gonadotropin secretion. Choose 5 cases 51 ~ 53 years old, amenorrhea more than three years of volunteers into