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目的研究肿瘤相关物质肿瘤特异性生长因子(TSGF)在肝癌、肝硬化及健康对照之间的差异性,从而探讨TSGF在肝癌与肝硬化诊断中的意义。方法采用光电比色法检测53例肝癌患者治疗前后以及66例健康体检者、60例肝硬化患者血清中TSGF的含量,并进行对比分析。结果肝癌治疗前TSGF明显高于对照组(t=31.67,P<0.01)及肝硬化组(t=12.77,P<0.01)。肝癌组治疗后与治疗前相比,TSGF明显降低(t=10.215,P<0.01)。结论血清TSGF测定对肝癌诊断具有较高的敏感性,且在监测治疗效果、转移及复发、人群普查等方面具有较大的实用价值。
Objective To investigate the difference of tumor-associated substance-specific growth factor (TSGF) in hepatocellular carcinoma, cirrhosis and healthy controls, so as to explore the significance of TSGF in the diagnosis of hepatocellular carcinoma and cirrhosis. Methods The levels of TSGF in serum of 53 patients with hepatocellular carcinoma before and after treatment, 66 healthy subjects and 60 patients with cirrhosis were detected by photoelectric colorimetry and compared with each other. Results The TSGF of hepatocellular carcinoma before treatment was significantly higher than that of control group (t = 31.67, P <0.01) and cirrhosis group (t = 12.77, P <0.01). TSGF was significantly lower in HCC group than before treatment (t = 10.215, P <0.01). Conclusion Serum TSGF is highly sensitive to the diagnosis of hepatocellular carcinoma, and has great practical value in monitoring the therapeutic effect, metastasis and recurrence and population census.