吡哌酸(Pipcmadic acid,PPA)是国内首创的新型全合成抗菌药,以抗革兰氏阴性杆菌为主,广泛用于肠道、胆道及泌尿系感染。吡哌酸口服吸收良好,在体内几乎不被代谢,由尿中以原药形式排泄,适宜用尿药法测定其生物利用度。本文应用紫外分光光度法于273nm测定添加不同辅料的胶囊剂的溶出度,于331nm测定其生物利用度。结果表明添加蔗糖粉的胶囊剂显示最佳溶出度及生物利用度。仪器与试药 UV-260紫外分光光度计,日本岛 Piperacillin (Pipcmadic acid, PPA) is the first new type of fully synthetic antibacterial drugs, resistant to gram-negative bacilli, widely used in intestinal, biliary and urinary tract infections. Pipemidic oral absorption of good, almost no metabolism in the body, excreted in the form of the original drug from the urine, suitable for determination of its bioavailability by urinary drug method. In this paper, UV spectrophotometry was used to determine the dissolution of capsules with different excipients at 273 nm. The bioavailability was determined at 331 nm. The results showed that capsules with sucrose powder showed the best dissolution and bioavailability. Instruments and reagents UV-260 UV spectrophotometer, the Japanese island