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以家兔在体记录胃电、十二指肠电、总胆管括约肌电和肝胆汁计滴为指标,观察吗啡、八肽胆囊收缩素对胃肠道平滑肌电活动的影响。结果表明,吗啡(0.2毫克/公斤,iv)可引起明显的抑制作用,八肽胆囊收缩素(0.25毫克╱公斤,iv)可产生增强作用。吗啡和八肽胆囊收缩素对胃肠道平滑肌电活动有相互拮抗作用,提出吗啡、八肽胆囊和纳洛酮有共同的竞争受体。吗啡不能完全解除乙酰胆碱的增强作用,八肽胆囊收缩素也不能完全解除去甲肾上腺素的抑制作用。推测内源性鸦片样肽和胆囊收缩素样肽可能同去甲肾上腺素和乙酰胆碱一起调节胃肠道的功能活动。
Rabbits in vivo records of gastric electrical, duodenal electricity, total biliary sphincter electricity and liver and gallbladder count as an indicator of morphine, octapeptide cholecystokinin gastrointestinal smooth muscle electrical activity. The results showed that morphine (0.2 mg / kg, iv) caused a significant inhibitory effect and octapeptide cholecystokinin (0.25 mg / kg, iv) produced potentiation. Morphine and octapeptide cholecystokinin have antagonistic effects on gastrointestinal smooth muscle electrical activity, suggesting that morphine, octapeptide gall bladder and naloxone have common competitive receptors. Morphine can not completely relieve the potentiation of acetylcholine, and octapeptide cholecystokinin can not completely eliminate the inhibitory effect of norepinephrine. It is speculated that endogenous opioid peptides and cholecystokinin-like peptides may regulate gastrointestinal functional activity along with norepinephrine and acetylcholine.