论文部分内容阅读
多药耐药基因ｍｄｒ1在正常大肠组织及其肿瘤中表达水平均较高 ,表现为天然性耐药 (ＭＤＲ)。然而大肠癌何以表现为天然性ＭＤＲ ?化疗药物通过何种机制致使ｍｄｒ1出现高表达 ?目前尚无定论。越来越多的分子生物学研究显示 ,肿瘤细胞对化疗应答的敏感性多取决于细胞的基因型 ,
Multidrug resistance gene mdr1 in normal colorectal tissues and their tumors were higher expression levels, the performance of natural resistance (MDR). However, why the performance of colorectal cancer MDR? Chemotherapy drugs through which mechanism led to the high expression of mdr1? It is not conclusive. More and more molecular biology studies show that the sensitivity of tumor cells to chemotherapy response depends on the cell’s genotype,