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目的探讨血清白细胞介素1(interleukin-1,IL-1)在妊娠期糖尿病(gestational diabetes mellitus,GDM)的临床应用价值。方法采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)检测48例妊娠糖尿病患者即GDM组、36例正常糖耐量(normal glucose tolerance,NGT)妊娠妇女即NGT组血清中IL-1水平,统计数据进行相关性分析。结果 (1)GDM组空腹血糖(fasting blood glucose,FBG)、稳态模型胰岛素抵抗指数(Homeostasis model as-sessment-insulin resistance,HOMA-IR)、IL-1水平均明显高于NGT组,两组差异有统计学意义(P﹤0.01)。(2)IL-1与HOMA-IR具有极显著正相关,相关系数为0.810,P﹤0.01。结论 IL-1与GDM具有相关性,可能均参与GDM的发生与发展,IL-1作为炎性因子可能会促进GDM的发生、发展。
Objective To investigate the clinical value of serum interleukin-1 (IL-1) in gestational diabetes mellitus (GDM). Methods Serum levels of IL-1 in 48 pregnant women with gestational diabetes mellitus (GDM) and 36 normal glucose tolerance (NGT) women were measured by enzyme-linked immunosorbent assay (ELISA) Data correlation analysis. Results (1) The levels of fasting blood glucose (FBG), homeostasis model as-sessment-insulin resistance (HOMA-IR) and IL-1 in GDM group were significantly higher than those in NGT group The difference was statistically significant (P <0.01). (2) There was a significant positive correlation between IL-1 and HOMA-IR with a correlation coefficient of 0.810 (P <0.01). Conclusion IL-1 and GDM are related and may all participate in the occurrence and development of GDM. IL-1 as an inflammatory factor may promote the occurrence and development of GDM.