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目的探讨强直性脊柱炎(ankylosing spondylitis,AS)对主动脉弹性的损害及其可能相关的因素。方法 40例AS患者(AS组)和40例体检健康者(对照组),2组行超声检查测定升主动脉应变率、膨胀系数和僵硬指数,分析其与体质量指数、病程、血清C反应蛋白等因素的相关性。结果 AS组体质量指数[(19.45±1.91)kg/m2]、升主动脉应变率[(10.56±2.12)%]、膨胀系数[(4.46±1.26)×10-6 cm2/dyne]低于对照组[(21.62±3.94)kg/m2、(12.46±2.74)%、(5.96±1.46)×10-6 cm2/dyne],僵硬指数(5.75±1.65)高于对照组(4.26±1.27),差异均有统计学意义(P<0.05);Pearson直线相关分析结果显示,AS患者升主动脉应变率(r=-0.316,P=0.047)、膨胀系数(r=-0.565,P=0.000)与病程呈负相关,僵硬指数(r=0.534,P=0.000)与病程呈正相关;升主动脉应变率、僵硬指数和膨胀系数与血清C反应蛋白、体质量指数均无相关性(P>0.05)。结论 AS可损害升主动脉弹性,损害程度与AS病程有一定相关性。
Objective To investigate the damage to aortic elasticity caused by ankylosing spondylitis (AS) and its possible related factors. Methods Forty patients with AS (AS group) and 40 healthy subjects (control group) underwent ultrasound examination to determine the ascending aorta strain rate, coefficient of thermal expansion and stiffness index. The relationship between them and body mass index, duration of disease, serum C reaction Protein and other factors related. Results The body mass index in AS group was significantly lower than that in control group [(19.45 ± 1.91) kg / m 2], ascending aorta strain rate (10.56 ± 2.12%), and expansion coefficient [(4.46 ± 1.26) × 10-6 cm2 / dyne] (21.62 ± 3.94) kg / m2, (12.46 ± 2.74)%, (5.96 ± 1.46) × 10-6 cm2 / dyne and stiffness index (5.75 ± 1.65) higher than the control group (4.26 ± 1.27) (R = -0.316, P = 0.047), the coefficient of expansion (r = -0.565, P = 0.000) and the course of disease The stiffness index (r = 0.534, P = 0.000) was positively correlated with the course of the disease. The ascending aorta strain rate, stiffness index and expansion coefficient had no correlation with serum C-reactive protein and body mass index (P> 0.05). Conclusion AS can damage ascending aortic elasticity, the degree of damage and the course of AS has some relevance.