为观察小檗碱对心脏保存的效果 ,我们将 0 .5mmol/L的小檗碱加入细胞内液型保存液———modifiedEuro Collins (mEC)液中 ,用小鼠Langendorff心脏灌注法 ,测定保存前后的心功能及心肌含水量。对照组为mEC液。保存时间为 4h ,保存后再次测定心功能。结果表明 :小檗碱组的LVPSP、-DP/Dtmax均较对照组好 ,差异显著 (P <0 .0 1,P <0 .0 5)。小檗碱组的心肌含水量少于对照组 ,差异显著 (P <0 .0 1)。说明小檗碱可以显著提高mEC液的心脏保存效果。 In order to observe the effect of berberine on the preservation of the heart, we added berberine (0.5 mmol/L) to the modified intracellular fluid (modifiedEuro Collins (mEC)), and then used the Langendorff heart perfusion method. Before and after the heart function and myocardial water content. The control group was an MCC solution. The preservation time was 4h, and the cardiac function was measured again after the preservation. The results showed that LVPSP and -DP/Dtmax were better in the berberine group than in the control group (P <0.01, P <0.05). The myocardial water content of the berberine group was less than that of the control group (P < 0.01). It was demonstrated that berberine can significantly improve the heart preservation effect of the mEC fluid.